… drug discovery and development, is a mathematical approach to study pharmacokinetics (PK),
pharmacodynamics … The PK model is an integration of a modified two-compartment model …

… how integrated pharmacokinetic–pharmacodynamic–… comprehensive approach to simulate
realistic treatment protocols and relate them to cost effectiveness in early drug development…

Frontiers | The importance of pharmacokinetics and pharmacodynamics in antimicrobial drug
development and their influence on the success of agents developed to combat resistant …

… and most efficacious medicines built upon rapid whole-genome sequencing drug-susceptibility …
actionable knowledge of antibiotic pharmacokinetics (PK) and pharmacodynamics (PD). …

… As such, the discipline is well integrated into the holistic drug discovery paradigm to optimize
ADME properties of molecules early and select drug candidates for entry into development. …

… pharmacodynamics of topiroxostat in vivo. This study highlights the important role of the …
model and drug–target residence time model in drug discovery and development process …

… We report integrated analyses of preclinical and clinical data that informed selection of the
recommended Phase II dose (RP2D) used in trilaciclib trials in extensive-stage small cell lung …

… in the pharmaceutical industry. At the research and drug development, PBPK has already
proven itself and is now an integral tool in drug discovery and development. It is a good tool for …

… These models integrated with various sensors show great potential in simulating the human
… to the fields of pharmacokinetics/pharmacodynamics, nano-medicine, continuous dynamic …

… in the body when a new drug molecule is administered as part of the pre… comprehensive
development in the organ-on-a-chip technology, various OOC models and its drug development …